Aktuelles zu Corona/Covid-19/Impfstoffe

Eine überwältigende Vielzahl wissenschaftlicher Erkenntnisse belegt, daß die  Hauptwirkungsweise der spike-basierten Covid-19-Impfstoffe, nämlich die Downregulation des Angiotensin-konvertierenden Enzyms 2 (ACE2) durch Spikes als verursachend für das vergleichsweise unverhältnismäßig umfangreiche Spektrum ihrer unerwünschten Wirkungen zu betrachten ist. Dieses Enzym ist ein wichtiger schützender Gegenregulator im Renin-Angiotensin-Aldosteron-System. Das Renin-Angiotensin-Aldosteron-System ist nicht nur für die kardiovaskuläre Homöostase verantwortlich, sondern über seinen wichtigsten vasokonstriktorischen Effektor, Angiotensin II, auch an entzündungsfördernden, gerinnungsfördernden, fibrotischen und immunologischen Wirkungen beteiligt. Dies könnte das Ausmaß und die Vielfalt des Spektrums an Nebenwirkungen erklären.

Andere Spike-Effekte (Zellfusion, Bindung an Heparansulfat, Aktivierung des Toll-like-Rezeptors 4), Synergismen (Anstieg von des-Arg9-Bradykinin, Katecholaminen) und eine Beeinträchtigung der intestinalen Aminosäureaufnahme ergänzen und vervielfachen die bereits nachteiligen Auswirkungen der spike-bedingten Herunterregulierung von ACE2 auf die Verträglichkeit.

Spike-basierte Covid-19-Impfstoffe zeichnen sich durch ein klassenspezifisches Profil unerwünschter Reaktionen aus. Ein kausaler Zusammenhang zwischen einem aktivierten Renin-Angiotensin-Aldosteron-System und vasokonstriktiven und ischämischen Folgeerscheinungen kann als erwiesen gelten. Daher sollte die Stimulation des Renin-Angiotensin-Aldosteron-Systems wie auch die gleichzeitige Einnahme von vasokonstriktiven, katecholaminergen oder TLR4- und DABK-aktivierenden und Heparansulfat-hemmenden Medikamenten für die Dauer der Spike-Wirksamkeit vermieden werden.

Es hat sich gezeigt, dass sich Impfstoffspikes systemisch verteilen und länger im Körper nachweisbar sind als bisher angenommen. Nach heutigem Kenntnisstand kann das Zeitfenster für die Beurteilung eines Kausalzusammenhangs zwischen Impfung und unerwünschten Reaktionen auf bis zu sechs Monate ausgedehnt werden.

Die Variabilität der unerwünschten Wirkungen dürfte insbesondere bei spikeinduzierenden Impfstoffen vergleichsweise hoch sein, da das Auftreten und die Schwere unerwünschter Reaktionen durch zahlreiche individuelle Faktoren und gegenregulatorische Mechanismen beeinflusst werden können. Hierzu liegen keine Erkenntnisse vor.

Die außergewöhnlich große Bandbreite, Häufigkeit und Schwere der gemeldeten unerwünschten Reaktionen im Zusammenhang mit der spike-basierten Covid-19-Impfung übersteigt das bekannte Niveau herkömmlicher Impfungen und gibt Anlass zu großer Sorge. Aus pharmakologischer Sicht sind Spikes hochwirksame Substanzen, aber keine harmlosen Antigene. Daher scheinen sie für eine vorbeugende Immunisierung gegen vergleichsweise harmlose Infektionen nicht geeignet zu sein.

ABSTRACT
The aim of this review is to provide explanations for many of the reported adverse reactions associated with spike-based Covid-19 vaccination and to draw appropriate conclusions.
Based on the comparatively disproportionate spectrum of adverse reactions of spike-based vaccines, an overwhelming body of evidence supports the consequences of the main mode of action of spike-based Covid-19 vaccines, namely the downregulation of angiotensin-converting enzyme 2 (ACE2) by spikes. This enzyme is a key protective counterregulator in the renin-angiotensin-aldosterone system. The renin-angiotensin-aldosterone system is not only responsible for cardiovascular homeostasis, but is also involved in pro-inflammatory, procoagulant, pro-fibrotic and immunological effects via its main vasoconstrictor effector, angiotensin II. This may explain the magnitude and diversity of the spectrum of side effects.
Other spike effects (cell fusion, binding to heparan sulphate, activation of Toll-like receptor 4), synergisms (increase in des-arg9-bradykinin, catecholamines) and impairment of intestinal amino acid uptake complement and multiply the already adverse effects of spike-related downregulation of ACE2 on tolerability.
Spike-based Covid-19 vaccines are characterised by a class-specific profile of adverse reactions. A causal relationship between an activated renin-angiotensin-aldosterone system and vasoconstrictive and ischaemic sequelae can be considered to be proven. Therefore, stimulation of the renin-angiotensin-aldosterone system and co-medication with vasoconstrictive, catecholaminergic or TLR4- and DABK-activating and heparan sulphate-inhibiting drugs should be avoided for the duration of spike efficacy.
It has been shown that vaccine spikes are distributed systemically and are detectable in the body for longer than previously thought. According to current knowledge, the time window for assessing a causal relationship between vaccination and adverse reactions can be extended to up to six months.
The variability of adverse effects is likely to be comparatively high, especially for spike-inducing vaccines, as the occurrence and severity of adverse reactions can be influenced by numerous individual factors and counter-regulatory mechanisms. There are no findings on this.
The exceptionally wide range, frequency and severity of reported adverse reactions associated with spike-based Covid-19 vaccination exceeds the known level of conventional vaccination and is a cause for serious concern. From a pharmacological point of view, spikes are highly potent substances, but they are not innocuous antigens. Therefore, they do not appear to be suitable for preventive immunisation against comparatively harmless infections.

The purpose of this review is to update the key findings from the scientific literature that provide explanations
for many of the reported and analyzed adverse effects associated with the spike-based COVID-19 vaccination.
An overwhelming body of evidence supports the main mode of action of spike-based COVID-19 vaccines,
namely the downregulation of ACE2 by spikes. Direct spike effects, synergisms and RAAS-independent
responses complement and multiply the already deleterious effects on tolerability.
It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate
ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The
systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and
short-lasting spike production and efficacy.
The exceptionally broad spectrum, frequency and severity of the reported ADRs associated with spike-based
COVID-19 vaccination exceed the known level of conventional vaccinations.
According to ADR analyses, the spike-based vaccines possess an unacceptable class-specific, unique ADR/side
effect profile.
From a pharmacological point of view, spikes are highly active substances, but not harmless antigens. For this
reason, they are not appropriate for preventive immunization to avoid comparatively harmless infections.

The purpose of this review is to update the key findings from the scientific literature that provide explanations for many of the reported and analysed adverse effects associated with the spike-based Covid-19 vaccination.

Principle results:

An overwhelming body of evidence supports the main mode of action of spike-based Covid-19 vaccines, namely the downregulation of ACE2 by spikes.  Direct spike effects, synergisms and RAAS-independent responses complement and multiply the already deleterious effects on tolerability.

It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and short-lasting spike production and efficacy.

The production volume of spikes, their dependencies and the non-neutralised spike proportion have so far remained unknown for unknown reasons.

Conclusions:

The exceptionally broad spectrum, frequency and severity of the reported side effects associated with spike-based Covid-19 vaccination exceed the known level of conventional vaccinations.

According to my side effect analyses, the spike-based vaccines possess an unacceptable class-specific, unique side effect profile.

From a pharmacological point of view, spikes are highly active substances, but not harmless  antigens. For this reason, they are not appropriate for preventive immunisation to avoid comparatively harmless infections.

The spectrum of side effects of spike-based COVID-19 vaccines is broader and more severe than generally recognised. Adverse cardiovascular events convincingly reflect the mode of action of the spikes, namely the downregulation of the cardiovascular protective angiotensin-converting enzyme 2
(ACE2), which leads to an increase in harmful angiotensin II concentrations and the associated consequences. A fundamental re-evaluation of the benefit-risk assessment of these novel vaccines is mandatory. Healthcare professionals should be educated about the consequences of spike-induced ACE2 downregulation, the resulting symptoms and therapeutic options.