There is no doubt that spike-inducing Covid-19 vaccines are associated with a complex and diverse range of side effects, which have significant health consequences for those affected. The known causes, primarily the activation of the renin-angiotensin-aldosterone system, as well as other induced and manipulated spike effects, are not sufficient enough to provide a plausible explanation for unusual clusters or the occurrence of rare side effects. This study aimed to investigate various adverse drug reactions that have not been observed, or have only rarely been observed, when using conventional vaccines. The analysis focused on the reaction groups following vaccination with the spike-inducing vaccines Tozinameran and Elasomeran: nervous system disorders, psychiatric disorders, musculoskeletal disorders, and general disorders. The data were retrieved from the EudraVigilance Web Reports and were interpreted based on an analysis of original research papers and review articles published in scientific journals. Among the most common adverse reactions from the aforementioned reaction groups were headaches (248,567 reports associated with Tozinameran, 90,948 reports following Elasomeran), fatigue (211,056 and 77,531 respectively), myalgia (156,735 and 62,034 respectively), asthenia (53,968 and 15,303 respectively), muscular weakness (10,882 and 3,328 respectively), anxiety/ fear (8,009 and 2,054 respectively), memory impairment/amnesia (6,475 and 2,132 respectively), depression/depressive mood (5,395 and 1,517 respectively), brain fog (3,685 and 992 respectively) and muscle twitching (3,605 and 908 respectively).
Recent findings suggest that further pathophysiological spike effects, which can significantly impair the bodys ability to maintain homeostasis, must be taken into account as possible causes. This involves an impairment of the cholinergic nervous system, which normally acts as a counter-regulatory mechanism, thereby promoting or exacerbating the undesirable activation of the renin-angiotensin-aldosterone system. Impairment of the cholinergic nervous system is caused by neurotoxin-like structures in the spike glycoprotein, which can trigger the inhibition of nicotinic-cholinergic receptors. Consequently, this can result in exacerbated inflammatory processes throughout the body, including the central nervous system. It may also result in activation of the sympathetic nervous system, thrombogenesis, pathological neuropsychiatric and musculoskeletal reactions, and an imbalance in the autonomic nervous system. Taken together, these factors may help to explain why there has been an increase in the incidence of adverse inflammatory and immunological reactions, cardiovascular reactions, coagulopathies, and neuropsychiatric and musculoskeletal disorders. However, in concrete terms, it depends on the organ-specific expression of counteracting regulators, on opposing regulatory effects, dose-dependent effects and time-dependent effects within the regulatory systems, as well as on comorbidities, age, gender, drug interactions and genetic predispositions.
Therapeutic intervention should be aimed at restoring and stabilising homeostasis. There are two main options for achieving this. Angiotensin receptor blockers are the preferred choice for inhibiting the renin-angiotensin-aldosterone system activation, specifically for counteracting the effects of the main effector, Angiotensin II. To activate and restore impaired cholinergic functions, particularly the cholinergic anti-inflammatory pathway, acetylcholine analogues, acetylcholinesterase inhibitors (e.g. donepezil and rivastigmine), and vagus nerve stimulation may be considered.

This analysis investigates mortality and relevant causes of death in Germany between 2019 and 2023, focusing particularly on the consequences of the SARS-CoV2 pandemic and mass vaccination campaigns.
Official, freely accessible annual statistics and government reports were used as sources to provide an overview of how the annual raw data has developed.
No `excess mortality` due to the pandemic in 2020 was detected that exceeded the level of the increase in deaths during the 2015 flu epidemic.
The years following the pandemic were characterised by widespread vaccination with spike-based mRNA-vaccines and basic immunisation rates exceeding 70%. Contrary to expectations, however, overall mortality increased by 3.797% in 2021 and by a further 4.31% in 2022 compared to the previous year. This represented an increase of 8.85% and 13.54% respectively compared to the pre-pandemic year. Even though the profile of the Covid-19 disease became less dangerous in the 2021 vaccination year and in the years that followed, the number of recorded deaths from the disease rose alarmingly (to 183.74% in 2021).
The available data suggest that overall mortality increased in 2021 and 2022, although the number of recorded Covid-19 deaths began to decline as early as 2022. There was a shift in the spectrum of causes of death, with an increase in fatal cardiovascular diseases, mental illnesses, and disorders of the nervous and digestive systems, and a decrease in respiratory diseases.
Given the profound mode of action of spike-based mRNA vaccines and their considerable potential for side effects, it is reasonable to suggest that they may contribute to the multifactorial causes of increased mortality.

Gleichgültig, ob durch einen „Untersuchungsausschuß“ oder eine „Enquetekommission“, es ist begrüßenswert, daß die menschengemachte Corona-Krise aufgearbeitet wird.  Die Beantwortung der Kardinalfrage, aus welchem Grund  die ungerechtfertigte Hochstufung der Gefährlichkeit der SARS-CoV2-Infektion im März 2020 erfolgte und wie es zu den katastrophal falschen Prognosen des Strategiepapiers des BMI kam, ist äußerst wichtig, denn sie lieferte den politischen Entscheidungsträgern die Argumente, die sie zur Auslösung der  unverhältnismäßigen, nicht-medizinischen Lock-Down-Maßnahmen veranlaßte. Auch die bedingte Zulassung der experimentellen unausgereiften Covid-19 Wirk-/Impfstoffe mit ihrem hohen Nebenwirkungspotential ist nur vor diesem Hintergrund möglich gewesen. Das Eintreten für eine Impfpflicht, offizielle Impfaufrufe und die Verunglimpfung von Nicht-Geimpften sind ebenso zu hinterfragen, wie die Ignoranz von Impfschäden und die Behinderung von Aufklärungsbemühungen.

Herkömmliche Impfstoffe genießen den Ruf ausreichender Effektivität und guter Verträglichkeit. Das Gegenteil erweist sich bei der Analyse von Wirksamkeit und Verträglichkeit der neuartigen, spike-basierten Covid-19 Impfstoffe (mRNA-, AdenoVirus- und proteinbasierte Wirk-/Impfstoffe). Unzureichender oder fehlender Impfschutz und insbesondere die Risiken bestimmen zunehmend den Diskurs. PEI, STIKO und die AkdÄ halten jedoch informationsresistent am Scheinkonzept eines sicheren Impfstoffes mit positiver Nutzen-Risiko-Bewertung fest. Die Vernachlässigung wissenschaftlicher Gründlichkeit und Wahrheitsfindung bei Analyse und Systematisierung der äußerst zahlreichen, vielfältigen und zum Teil gefährlichen Nebenwirkungen verhinderte den notwendigen Erkenntnisgewinn und dessen Weitergabe. Dem Gros der nicht eigenständig Recherchierenden fehlen aus diesen Gründen seit Beginn der Impfkampagne grundlegende Informationen zum Nebenwirkungsprofil und seiner Verursachung. Deshalb verwundert es nicht, daß die sogen MedSafetyWeek (4.-10.11.2024), die eine Sensibilisierung gegenüber Nebenwirkungs-meldungen  bezweckte,  für Covid-19 Impfstoffe in Deutschland gänzlich ins Leere lief.

Eine überwältigende Vielzahl wissenschaftlicher Erkenntnisse belegt, daß die  Hauptwirkungsweise der spike-basierten Covid-19-Impfstoffe, nämlich die Downregulation des Angiotensin-konvertierenden Enzyms 2 (ACE2) durch Spikes als verursachend für das vergleichsweise unverhältnismäßig umfangreiche Spektrum ihrer unerwünschten Wirkungen zu betrachten ist. Dieses Enzym ist ein wichtiger schützender Gegenregulator im Renin-Angiotensin-Aldosteron-System. Das Renin-Angiotensin-Aldosteron-System ist nicht nur für die kardiovaskuläre Homöostase verantwortlich, sondern über seinen wichtigsten vasokonstriktorischen Effektor, Angiotensin II, auch an entzündungsfördernden, gerinnungsfördernden, fibrotischen und immunologischen Wirkungen beteiligt. Dies könnte das Ausmaß und die Vielfalt des Spektrums an Nebenwirkungen erklären.

Andere Spike-Effekte (Zellfusion, Bindung an Heparansulfat, Aktivierung des Toll-like-Rezeptors 4), Synergismen (Anstieg von des-Arg9-Bradykinin, Katecholaminen) und eine Beeinträchtigung der intestinalen Aminosäureaufnahme ergänzen und vervielfachen die bereits nachteiligen Auswirkungen der spike-bedingten Herunterregulierung von ACE2 auf die Verträglichkeit.

Spike-basierte Covid-19-Impfstoffe zeichnen sich durch ein klassenspezifisches Profil unerwünschter Reaktionen aus. Ein kausaler Zusammenhang zwischen einem aktivierten Renin-Angiotensin-Aldosteron-System und vasokonstriktiven und ischämischen Folgeerscheinungen kann als erwiesen gelten. Daher sollte die Stimulation des Renin-Angiotensin-Aldosteron-Systems wie auch die gleichzeitige Einnahme von vasokonstriktiven, katecholaminergen oder TLR4- und DABK-aktivierenden und Heparansulfat-hemmenden Medikamenten für die Dauer der Spike-Wirksamkeit vermieden werden.

Es hat sich gezeigt, dass sich Impfstoffspikes systemisch verteilen und länger im Körper nachweisbar sind als bisher angenommen. Nach heutigem Kenntnisstand kann das Zeitfenster für die Beurteilung eines Kausalzusammenhangs zwischen Impfung und unerwünschten Reaktionen auf bis zu sechs Monate ausgedehnt werden.

Die Variabilität der unerwünschten Wirkungen dürfte insbesondere bei spikeinduzierenden Impfstoffen vergleichsweise hoch sein, da das Auftreten und die Schwere unerwünschter Reaktionen durch zahlreiche individuelle Faktoren und gegenregulatorische Mechanismen beeinflusst werden können. Hierzu liegen keine Erkenntnisse vor.

Die außergewöhnlich große Bandbreite, Häufigkeit und Schwere der gemeldeten unerwünschten Reaktionen im Zusammenhang mit der spike-basierten Covid-19-Impfung übersteigt das bekannte Niveau herkömmlicher Impfungen und gibt Anlass zu großer Sorge. Aus pharmakologischer Sicht sind Spikes hochwirksame Substanzen, aber keine harmlosen Antigene. Daher scheinen sie für eine vorbeugende Immunisierung gegen vergleichsweise harmlose Infektionen nicht geeignet zu sein.

ABSTRACT
The aim of this review is to provide explanations for many of the reported adverse reactions associated with spike-based Covid-19 vaccination and to draw appropriate conclusions.
Based on the comparatively disproportionate spectrum of adverse reactions of spike-based vaccines, an overwhelming body of evidence supports the consequences of the main mode of action of spike-based Covid-19 vaccines, namely the downregulation of angiotensin-converting enzyme 2 (ACE2) by spikes. This enzyme is a key protective counterregulator in the renin-angiotensin-aldosterone system. The renin-angiotensin-aldosterone system is not only responsible for cardiovascular homeostasis, but is also involved in pro-inflammatory, procoagulant, pro-fibrotic and immunological effects via its main vasoconstrictor effector, angiotensin II. This may explain the magnitude and diversity of the spectrum of side effects.
Other spike effects (cell fusion, binding to heparan sulphate, activation of Toll-like receptor 4), synergisms (increase in des-arg9-bradykinin, catecholamines) and impairment of intestinal amino acid uptake complement and multiply the already adverse effects of spike-related downregulation of ACE2 on tolerability.
Spike-based Covid-19 vaccines are characterised by a class-specific profile of adverse reactions. A causal relationship between an activated renin-angiotensin-aldosterone system and vasoconstrictive and ischaemic sequelae can be considered to be proven. Therefore, stimulation of the renin-angiotensin-aldosterone system and co-medication with vasoconstrictive, catecholaminergic or TLR4- and DABK-activating and heparan sulphate-inhibiting drugs should be avoided for the duration of spike efficacy.
It has been shown that vaccine spikes are distributed systemically and are detectable in the body for longer than previously thought. According to current knowledge, the time window for assessing a causal relationship between vaccination and adverse reactions can be extended to up to six months.
The variability of adverse effects is likely to be comparatively high, especially for spike-inducing vaccines, as the occurrence and severity of adverse reactions can be influenced by numerous individual factors and counter-regulatory mechanisms. There are no findings on this.
The exceptionally wide range, frequency and severity of reported adverse reactions associated with spike-based Covid-19 vaccination exceeds the known level of conventional vaccination and is a cause for serious concern. From a pharmacological point of view, spikes are highly potent substances, but they are not innocuous antigens. Therefore, they do not appear to be suitable for preventive immunisation against comparatively harmless infections.

The purpose of this review is to update the key findings from the scientific literature that provide explanations
for many of the reported and analyzed adverse effects associated with the spike-based COVID-19 vaccination.
An overwhelming body of evidence supports the main mode of action of spike-based COVID-19 vaccines,
namely the downregulation of ACE2 by spikes. Direct spike effects, synergisms and RAAS-independent
responses complement and multiply the already deleterious effects on tolerability.
It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate
ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The
systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and
short-lasting spike production and efficacy.
The exceptionally broad spectrum, frequency and severity of the reported ADRs associated with spike-based
COVID-19 vaccination exceed the known level of conventional vaccinations.
According to ADR analyses, the spike-based vaccines possess an unacceptable class-specific, unique ADR/side
effect profile.
From a pharmacological point of view, spikes are highly active substances, but not harmless antigens. For this
reason, they are not appropriate for preventive immunization to avoid comparatively harmless infections.

The purpose of this review is to update the key findings from the scientific literature that provide explanations for many of the reported and analysed adverse effects associated with the spike-based Covid-19 vaccination.

Principle results:

An overwhelming body of evidence supports the main mode of action of spike-based Covid-19 vaccines, namely the downregulation of ACE2 by spikes.  Direct spike effects, synergisms and RAAS-independent responses complement and multiply the already deleterious effects on tolerability.

It has been repeatedly confirmed that the SARS-CoV spike protein alone is not only able to downregulate ACE2, but also to induce cell fusion, activation of TLR4, of co-receptors and gastrointestinal responses. The systemic and long-lasting detection of spikes after vaccination disproves the claimed regionally limited and short-lasting spike production and efficacy.

The production volume of spikes, their dependencies and the non-neutralised spike proportion have so far remained unknown for unknown reasons.

Conclusions:

The exceptionally broad spectrum, frequency and severity of the reported side effects associated with spike-based Covid-19 vaccination exceed the known level of conventional vaccinations.

According to my side effect analyses, the spike-based vaccines possess an unacceptable class-specific, unique side effect profile.

From a pharmacological point of view, spikes are highly active substances, but not harmless  antigens. For this reason, they are not appropriate for preventive immunisation to avoid comparatively harmless infections.

The spectrum of side effects of spike-based COVID-19 vaccines is broader and more severe than generally recognised. Adverse cardiovascular events convincingly reflect the mode of action of the spikes, namely the downregulation of the cardiovascular protective angiotensin-converting enzyme 2
(ACE2), which leads to an increase in harmful angiotensin II concentrations and the associated consequences. A fundamental re-evaluation of the benefit-risk assessment of these novel vaccines is mandatory. Healthcare professionals should be educated about the consequences of spike-induced ACE2 downregulation, the resulting symptoms and therapeutic options.